Nickel phosphide for MRI-guided synergistic photo-immunotherapy

Developing a phototherapy modality to ablate tumor and then trigger immunogenic cell death (ICD) for simultaneously eliminating distal and metastatic tumors holds great promise in clinical applications. Herein, the polyethylene glycol functionalized Ni 2 P (Ni 2 [email protected] NPs) is developed with enhanced biocompatibility, high photoabsorption and photothermal efficiency, as well as reactive oxygen species generation ability. Of particular note, Ni 2 [email protected] NPs mediated phototherapy could not only realize efficient ablation of primary tumors, but also inhibit distal tumors and metastatic tumors by triggering an antitumor immune response. The above conclusions were verified by B mode ultrasound, western blot assay, and immunohistochemistry analysis. Meanwhile, Ni 2 [email protected] NPs showed excellent magnetic resonance imaging (MRI) properties. In summary, the MRI-guided multimodal cancer therapies of Ni 2 [email protected] NPs represent significant potential for clinical applications.