Low-density Pt nanoarray-based hydrogen peroxide sensing platform and its application in trace sarcosine detection

Hydrogen peroxide (H 2 O 2 ) is an important signaling molecule that regulates many biological processes. It is of great value to realize rapid, accurate, highly sensitive and low-cost H 2 O 2 detection in the immediate detection of trace disease markers. Low-density nanoelectrode arrays have a high signal-to-noise ratio and are advantageous for trace detection. In this paper, low-density Pt nanoelectrode arrays were successfully prepared by a simple method of ion sputtering combined with electrodeposition based on a track-etched polycarbonate membrane template. The arrays had a detection limit as low as 0.03 μM for H 2 O 2 at a constant potential, a sensitivity of 125.9 μA mM −1 , and a linear range spanning nearly four orders of magnitude (0.1–655 μM). The developed sarcosine sensors based on these arrays had a very low detection limit (0.08 μM) and wide linear range (0.5–64.5 μM) for the rapid detection of trace amounts of sarcosine in serum. With a wide linear range and low detection limits, this hydrogen peroxide sensing platform has great potential for use in the rapid electrochemical detection of trace substances.