Litchi-like glucose oxidase-integrated magnetic metal-organic framework as glucose-triggered cascade catalyst for antibacterial treatment

The abuse of conventional antibiotic is considered to be one of the main factors hindering the healing of bacteria-infected wound, which has severely threatened the public health. Reactive oxygen species (ROS), such as the common commercial H 2 O 2 have been used as a healing strategy to combat wound infection. However, the low efficiency limits its application. Herein, a litchi-like glucose oxidase-integrated magnetic metal-organic framework (pFe 3 O 4 @MOF-GOx) with satisfactory biocompatibility has been constructed as glucose-triggered cascade reagent for antibacterial application. The immobilized glucose oxidase (GOx) can catalyze the decomposition of non-toxic glucose into H 2 O 2 and gluconic acid. Subsequently, the generated H 2 O 2 is catalyzed by the intrinsic peroxidase-like of pFe 3 O 4 @MOF to produce toxic hydroxyl radicals . In vitro antibacterial investigations demonstrate the synthesized hybrids display broad-spectrum antibacterial performance with the presence of glucose. Meanwhile, external H 2 O 2 is not required in this developed strategy, which avoids the undesired damage to normal tissues caused by the H 2 O 2 with relatively high concentration in peroxidase-like system. Altogether, the construction of glucose-triggered cascade strategy with effective antibacterial activity provides an alternative method for the treatment of bacterial infected wound.