Integrated Microsystem Toward High-Throughput Automated Green Synthesis and Raman Enhancement Performance Screening of Noble-Metal@Cu-MOF

“Green Synthesis” has been broadly applied in drug synthesis and nanomaterial preparation. The integration of automated micro-synthesis and high-throughput screening systems is a key way to achieve the goal of green manufacturing. Here, a one-click green synthesis platform is designed that integrates droplets arrays-based micro-synthesis for Raman enhancement performance high-throughput screening of MNPs@Cu-MOF (AuNPs@, AgNPs@, PtNPs@Cu-MOF) under room temperature and normal pressure. The fully integrated ultrasound units can achieve rapid multi-component mixing in the droplet array systems, and significantly accelerate materials growth as well as enhance encapsulation of noble metal nanoparticles into Cu-MOF structures. Based on such integrated systems, structures with high Raman enhancement performance can be high-throughput evaluation and easily screened out. The results indicated that the AgNPs@Cu-MOF exhibited the best Raman enhancement performance, which is ≈8 times higher than pure AgNPs. Such a green and integrated platform provides a way for automated multi-type composites fabrication, which can be expanded to multiple fields in the future via combined robotic platforms and artificial intelligence technology.