Metal-organic frameworks-based broad-spectrum sensor for total tetracycline antibiotics assay

Although development of sensors being capable of a specific tetracycline antibiotics detection has been extensively documented recently, total quantification of this harmful antibiotics seems to be more imperative from the perspective of environmental monitoring. In this work, 5-aminoisophthalic acid-based metal-organic framework (Zn/H 2 aip) probe was presented for total tetracyclines detection including tetracycline (TC), oxytetracycline (OTC), doxycycline (DOX) and chlortetracycline (CTC) based on fluorescence method. The prepared probe solution displayed a fluorescence quenching response at 403 nm together with an obvious fluorescence enhancement at about 520 nm to the four tetracyclines, realizing a ratiometric fluorescence response of the probe to the targets. In addition to mechanism study behind this phenomenon by experiments including UV–vis, fluorescence and infrared spectroscopy, the stability and reusability of the proposed probe was investigated for the evaluation of its potential in practical application.