Sensitive determination of ascorbic acid, dopamine and uric acid by glassy carbon electrodes modified with β-cyclodextrin and graphene oxide

In this paper, an ultra-sensitive glassy carbon electrode modified with β-cyclodextrin and graphene oxide (β-CD-GO/GCE) has been prepared for the detection of biomolecules [ascorbic acid (AA), dopamine (DA) and uric acid (UA)] in aqueous solution at μM level. The three biomolecules (AA, DA and UA) can be simultaneously detected by the modified electrodes, and the electrical signals corresponding to various biomolecules can be identified clearly in cyclic voltammetry and differential pulse voltammetry curves. The simultaneous detection limits of AA, DA, UA were 4.58, 1.56, 1.27 μM, respectively. This ultra-sensitivity should be attributed to the formation of host–guest complexes between β-CD and the biomolecules. Furthermore, the anti-interference experiments indicated the β-CD-GO/GCE exhibited satisfactory selective recognition performance.