Preparation of temperature-controlled shrinkage PTMC/PVP core-shell nanofibrous membrane with spindle-knotted structure for accelerating wound closure

Temperature-controlled shrinkage polytrimethylene carbonate (PTMC)/polyvinylpyrrolidone (PVP) core–shell nanofibrous membranes were successfully prepared by uniaxial electrospinning to accelerate wound closure. The characterization and temperature-controlled shrinkage of the PTMC/PVP nanofibrous membranes were investigated. The results showed that the PTMC/PVP core–shell nanofibers had a periodic distribution of porous spindle-knotted structure, and EDS elemental mapping of N elements indicated the core–shell structure with PTMC shell and PVP core. The PTMC/PVP (1:3) nanofibrous membrane had the maximum shrinkage in PBS for 120 min, which area percentage were decreased to 68.0% at 20 °C and 49.4% at 37 °C. The results indicated that the PTMC/PVP nanofibrous membranes shrinkage would be increased with the temperature increased. Further experiments confirmed the PTMC/PVP (1:3) nanofibrous membrane could reduce the wound area of rat skin to approximately 70% in 30 min.