Electrospun SF/PLGA/ICG Composite Nanofibrous Membranes for Potential Wound Healing and Tumor Therapy

Indocyanine green (ICG) is a near-infrared (NIR) organic reagent for clinical bioimaging and phototherapy. It is a suitable photosensitizer for photodynamic antimicrobial chemotherapy (PACT). In this study, various ICG-loaded nanofibrous membranes were prepared. The water vapor transmission rate (WVTR) of SF/PLGA/20ICG was 3040.49 ± 157.11 g·m−2day−1, which allowed the maintenance of a humid environment above the wound. The growth inhibition rates forS. aureusandE. coliwere 91.53% and 87.95%, respectively. The nanofibrous membranes exhibited excellent antimicrobial performance. Cellular experiments showed that the nanofibrous membranes have good cytocompatibility and antitumor efficacy. SF/PLGA/20ICG showed good potential for application in wound healing and cancer therapy.Keywords:indocyanine green;nanofibrous membranes;near-infrared;controlled release