Synergistic combination: Promising nanoplatform W-POM NCs@ HKUST-1 for photothermal and chemodynamic reinforced anti-tumor therapy

Chemodynamic therapy (CDT) uses the conversion of H 2 O 2 to ·OH triggered by Fenton-like reactions to treat tumors, but the treatment is not complete due to insufficient intracellular H 2 O 2 content. Photothermal therapy (PTT) uses photothermal materials for photothermal conversion to kill tumors, but it is limited by the extent of exogenous light transmission and cannot achieve satisfactory therapeutic effects. Therefore, designing a composite nanomaterial that amplifies CDT and couples it with PTT for tumor treatment is a major challenge. Herein, we designed a W-POM NCs@HKUST-1 nanoplatform that combines PTT and CDT and has better targeting properties. It shows high stability and photothermal conversion efficiency under the irradiation of near-infrared light and efficiently catalyzes the generation of intracellular hydroxyl radicals, this composite material exhibits higher lethality than single therapeutic strategies. This study expands the application area of POM@MOF composite nanomaterials and provides a promising means of enhanced tumor therapy.