Hydrothermal Deposition of PCN-224 on 3D-Printed Porous β-Ca2SiO4 Scaffolds for Bone Regeneration

3D-printed bioceramics derived from silicone resin are of great interest in bone tissue engineering owing to their simple processes and low cost. Herein, PCN-224, as a subclass of metal−organic frameworks (MOFs), is successfully fabricated and deposited on the surface of 3D-printed porous β-Ca 2 SiO 4 (C 2 S) scaffolds. The composite scaffolds possess uniform interconnected macropores (≈400 μm), with increased porosity and slower degradation. The results indicate that deposition of PCN-224 significantly promotes cell proliferation and the expression of osteogenesis-related genes. Moreover, the composite scaffolds significantly improve calvarial defect healing in rats, compared with C 2 S scaffolds. Therefore, the PCN-224-modified 3D-printed porous C 2 S composite scaffolds are promising candidates for bone tissue engineering.