A novel electrochemical platform based on COF/La2O3/MWCNTS for simultaneous detection of dopamine and uric acid

In this present paper, a novel electrochemical sensor based on a covalent organic framework (COF) and lanthanum oxide (La 2 O 3 ) and multi-wall carbon nanotubes (MWCNT S ) was prepared for sensitive and selective detection of dopamine (DA) and uric acid (UA). The sensor demonstrated excellent analytical performance for DA and UA owing to the synergistic effect among large surface area of COF, highly conducting MWCNTs and highly catalytic La 2 O 3 . Particularly, the COF with a BET surface area of 1396.04 m 2 /g prepared by the Schiff base reaction between 2, 5-dibromobenzene-1, 4-dicarbaldehyde (DBTA) and 2, 4, 6-tris(4-aminophenyl)− 1, 3, 5-triazine (TAPT), significantly enhanced the adsorption and enrichment ability of the resulted modified electrode toward the target molecules. The constructed electrochemical sensor possessed low detection limits (0.039 μM for DA and 0.024 μM for UA) and wide linear ranges (2 ~ 450 μM for DA and 0.4 ~ 450 μM for UA) and could be employed to detect simultaneously the contents of DA and UA in biological and medicine samples with outstanding reproducibility, high stability as well as strong anti-interference property.