Two new isoquinoline alkaloids from Cryptocarya wrayi and their biological activities

Two new isoquinoline alkaloids , cryptowrayines A ( 1 ) and B ( 2 ), along with one known pavine alkaloid (-)-12-hydroxyeschscholtzidine ( 3 ), were isolated from the twigs of Cryptocarya wrayi . The structures of new compounds were elucidated by extensive spectroscopic data analysis and electronic circular dichroism (ECD) calculations. Both compounds 1 and 2 exhibited moderate quinone reductase inducing activity in Hepa 1c1c7 cells.