Sol-gel coating loaded with inhibitor on ZE21B Mg alloy for improving corrosion resistance and endothelialization aiming at potential cardiovascular application

To improve the service performance of vascular stents, we designed/selected a series of organic compounds from commercial drugs, natural plants, and marine life as the potential corrosion inhibitors for ZE21B alloy. Paeonol condensation tyrosine (PCTyr) Schiff base was found to be the most efficient inhibitor among them. The biocompatible, self-healing, anti-corrosive sol-gel coating loaded with corrosion inhibitor was fabricated on the Mg substrate through a convenient dip-coating tactic. The corrosion resistance, self-healing ability, cytotoxicity, and hemocompatibility of the coated sample were evaluated. These results suggested the potentiality of Schiff base inhibitor-loaded sol-gel coating for enhanced corrosion protection and desired biocompatibility of bioabsorbable cardiovascular implants.