PEG Modificated Bubble-Like Carbon Spherical-W18O49 Using for In Vitro Chemotherapy-Photothermal Synergistic Reverse Cancer Cells

In this study, a chemotherapy-photothermal synergistic anti-tumor system is constructed. Both W 18 O 49 @R-C and PEG-W 18 O 49 @R-C synthesized by hydrothermal method show the potential of photothermal therapy (PTT). The structure of reflux-carbon is bubble-like spherical and W 18 O 49 @R-C obtained by hydrothermal synthesis will cause bubble collapse due to the formation of crystal W 18 O 49 ; thus, the particle size decreases sharply. Furthermore, the photothermal stability of PEG-W 18 O 49 @R-C is higher than that of W 18 O 49 @R-C, and ζ-potential measurement indicates that PEG-W 18 O 49 @R-C has excellent dispersion characteristics. The test of drug loading and drug release performance show that PEG-modified W 18 O 49 @R-C has superior performance on drug loading amount and release capacity. In the synergistic anti-tumor process, the cancer cell viability after co-incubating with PEG-W 18 O 49 @R-C+DOX . HCl (with 808nm) is only 16.6%. These results indicate that PEG-W 18 O 49 @R-C has potential in the treatment of cancer by a combination of PTT and chemotherapy.