Thermodynamic modelling for solubility of methyl 2-sulfamoylbenzoate in sixteen organic solvents from T (272.15–324.15 K) and dissolution properties

The solubility and solution thermodynamics of methyl 2-sulfamoylbenzoate (MeSAB) in different solvents are essential for the design, optimization and control of its solution crystallization process . In this study, the solubility of MeSAB in sixteen mono solvents including methanol, ethanol, n -propanol, isopropanol, n -butanol, isobutanol , n -pentanol, isopentanol, 2-butanone, acetone, ethyl acetate , 2-pentanone, acetonitrile , methyl acetate , ethyl formate and cyclopentanone was obtained through a gravimetric method within the temperature range from 272.15 to 324.15 K under ambient pressure. The highest and lowest solubility of MeSAB was observed in ketones and alcohols, respectively. At fixed temperatures, the solubility data rank as cyclopentanone  > acetone > 2-butanone >  acetonitrile  > 2-pentanone ≈ methyl acetate  >  ethyl acetate  >  ethyl formate  > methanol > ethanol > n-propanol > isopropanol > n-butanol > n-pentanol > isopentanol ≈ isobutanol . The experimental solubility can be well correlated using the Apelblat equation, λh equation, non-random two-liquid (NRTL) model and the Wilson model. The obtained maximum relative average deviation ( RAD ) and root-mean-square deviation ( RMSD ) were 6.74 × 10 −3 and 5.61 × 10 −4 respectively. Besides, the dissolution enthalpy, entropy, and Gibbs free energy were calculated on the basis of thermodynamic relations and the Wilson model, which revealed that the dissolution of MeSAB was a spontaneous and endothermic process.