Fabrication of Photoelectrochemical Sensor Based on Fe-Doped MoSe2 for the Sensitive Detection of Berberine Hydrochloride

In this study, a novel photoelectrochemical (PEC) sensor based on FeMoSe2 was developed for the detection of berberine hydrochloride (BRH). The photosensitive material Fe-doped MoSe2 (FeMoSe2) was prepared by a simple hydrothermal method. Compared with MoSe2, FeMoSe2 shows superior PEC performance for the sensitive detection of BRH under blue light. Under the best experimental conditions, the PEC sensor presented a wide detection range of 0.025–15.0 μM with a detection limit of 8.4 nM. Therefore, the PEC sensor is considered an effective analytical method for detecting BRH. Moreover, the PEC sensor has good reporducibility and stability. Eventually, the proposed sensor was successfully applied to detect two different types of BRH tablets. This project provides a new pathway for detecting BRH.