An Enzyme-free Electrochemical H2O2 Sensor Based on a Nickel Metal-organic Framework Nanosheet Array

In this work, we reported the development of a nickel metal-organic framework nanosheet array on Ti-mesh (Ni-MOF/TM) as an enzyme-free electrochemical sensing platform for H 2 O 2 determination. The as-obtained sensor exhibited outstanding detection properties of H 2 O 2 , which might be gifted from the large specific surface area, abundant active sites of Ni-MOF nanoarrays. The sensor displayed a good linear range (0.8 μM–4.6×10 3 μM), a detection limit as low as 0.26 μM, a high sensitivity (307.5 μA mM −1 cm −2 ), and a rapid response. Moreover, this enzyme-free sensor is promising for point-of-care (POC) testing of H 2 O 2 in human serum attribute to the excellent performance of Ni-MOF and the simple preparation process of the sensor.