Study on the solubilization of telmisartan by forming cocrystals with aromatic carboxylic acids

The solubility of insoluble telmisartan (TEL) was improved by forming new cocrystal forms with several aromatic carboxylic acids. All solid forms showed three dissolution modes: TEL–HBA achieved the maximum release equilibrium within 30 min and maintained a stable and efficient dissolution level within 6 h. TEL–3-HBA and TEL–2,5-DHBA showed a slowly declining trend over time up to 6 h. TEL–3,5-DHBA conformed to the “spring and parachute” model. The TEL–HBA mixture was the most stable and was selected for further thermodynamic study, which found a 1 : 1 complexation with HCl (0.1 M) solution.