A novel nanozyme comprised of electro-synthesized molecularly imprinted conducting PEDOT nanocomposite with graphene-like MoS2 for electrochemical sensing of luteolin

A novel nanozyme sensor based on the electro-synthesized molecularly imprinted conducting poly(3,4-ethylenedioxythiophene) (PEDOT) nanocomposite with graphene-like two-dimensional layered molybdenum disulfide (MoS 2 ) was successfully prepared for electrochemical detection and analysis of luteolin in Gnaphalium affine. MoS 2 -MIPs were prepared facilely by electrochemical polymerization of monomer 3,4-ethylenedioxythiophene in the presence of both modifier MoS 2 and template molecule luteolin that can change the morphological structure and specific surface area of PEDOT, enhance electronic conductivity of MoS 2 , and improve the recognition capability and electrocatalytic capacity of electrode interface. The morphological structure of MoS 2 -MIPs was characterized by SEM, and its electrochemical performance and sensing parameters were investigated by voltammetry. The electrochemical response of luteolin was recorded by MoS 2 -MIPs in the linear concentration range from 3 × 10 -7 to 3 × 10 -5 Μ with limit of detection of 0.04 μΜ under the optimal conditions, which was successfully employed for electrochemically detecting luteolin in Gnaphalium affine with acceptable recoveries in comparison with high-performance liquid chromatography. This will provide a new nanozyme sensing platform comprised of electro-synthesized molecularly imprinted conducting polymers and graphene-like two-dimensional layered nanomaterials.