A composite prepared from covalent organic framework and gold nanoparticles for the electrochemical determination of enrofloxacin

A high conductivity composite based on covalent organic frameworks/gold nanoparticles (TAPB-PDA-COFs/AuNPs, TAPB: 3,5-tris(4-aminophenyl)benzene, PDA: p-phthalaldehyde) was prepared by a simple in-situ synthesized method and a novel electrochemical sensor based on TAPB-PDA-COFs/AuNPs was constructed for detection of Enrofloxacin (ENR). A variety of different characterization techniques including ultraviolet‐visible spectrophotometer (UV–vis), fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) were used to characterize the TAPB-PDA-COFs/AuNPs. ENR was detected by square wave stripping voltammetry (SWV) according to the relationship between the ENR concentration and the oxidation peak current. The result showed that TAPB-PDA-COFs/AuNPs was synthesized successfully. The electrochemical sensor showed two linear ranges in the range of 0.05–10 μmol L −1 and 10–120 μmol L −1 with the limit of detection of 0.041 μmol L −1 (S/N = 3). The good recoveries (96.7–102.2%) and low RSDs (0.9–6.4%) indicated the possibility of using this sensor for actual sample detection. Therefore, TAPB-PDA-COFs/AuNPs-based electrochemical sensor showed good performance in detecting ENR, and would be a potential candidate for the development of fluoroquinolones determination.