A general strategy to synthesis chitosan oligosaccharide-O-Terpenol derivatives with antibacterial properties

The objectives of the present study are to synthesize a series of chitosan oligosaccharide-O-Terpenol (COS–O-Ter) derivatives and their implication to evaluate in vitro antibacterial activity . Herein, a general strategy is described for preparing COS–O-Ter derivatives, including substitution and deprotection reactions . The structures of COS–O-Ter derivatives were characterized by FT-IR, 1 H NMR, XRD, TGA , and elemental analysis . COS–O-Ter derivatives revealed the excellent solubility and in vitro antibacterial activity. Moreover, their antibacterial activities were more sensitive to Staphylococcus aureus ( S. aureus ) than Escherichia coli ( E. coli ) indicating the effective potential application of COS–O-Ter derivatives as natural antibacterial agents . The aforementioned study opens a pave to expand the application scope of COS and its derivatives in the food and pharmaceutical industries .