Cu2O hollow microspheres as electrode materials for non-enzymatic electrochemical detection of glucose

An enzyme-free glucose electrochemical sensor with high sensitivity and selectivity is highly attractive. In this work, an enzyme-free glucose sensor with Cu 2 O hollow microspheres (Cu 2 O HMs) was prepared via hydrothermal method. The glucose sensor constructed by the prepared Cu 2 O HM structure exhibited a low detection limit of 0.13 μM, a high sensitivity of 277.1 μA/mM cm 2 , and the wide linear ranges of 0.05–1.5 and 1.5–6.0 mM. Furthermore, anti-interference tests indicated that the prepared sensor exhibited good selectivity for glucose and practical application in human serum. The Cu 2 O sensor has great application potential in the development of enzyme-free glucose sensor.