已核实 DOI 相关产品: 99

Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy

Journal 2020 · IF 8.183 · 14(7): 2398-2409 · 发表于 2020 年 12 月 29 日
作者: Zhang Zhicheng,Ding Yawen,Li Jinbiao,Wang Li,Xin Xiaoyan,Yan Jing,Wu Jinhui,Yuan Ahu,Hu Yiqiao
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摘要

Ferroptosis is a newly form of regulated cell death, which has attracted great attention for tumor therapy. Herein, we prepared nanoscale coordination polymer Fe-NQA particles to deliver iron and NQA (vitamin K 3 derivative) into tumor cells, which synergistically promoted ferroptotic therapy for inhibiting tumor growth, preventing metastasis, and overcoming radioresistance.

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