A cage-based covalent organic framework for drug delivery

A novel cage-based crystalline covalent organic framework, i.e. Cage-COF-TT (TT = triammonia–terephthalaldehyde), was prepared from a prism-like triammonia-containing molecular cage and terephthalaldehyde. Its ordered structure and porosity are expected to ensure efficient drug delivery as a potent carrier. The excellent cell viability of Cage-COF-TT was testified through MTT assays with respect to both normal mouse cells and normal human hepatocyte cells. In terms of drug delivery performance, Cage-COF-TT exhibit a high loading capacity and efficient drug release profile in a simulated body fluid environment. This work offers new insights into the design and development of a COF-based drug carrier and inspires the development of versatile tools for biomedical applications.