Nanoparticle-Loaded Polarized-Macrophages for Enhanced Tumor Targeting and Cell-Chemotherapy

A polarized-macrophages-based drug delivery system (M1/SLNP) was presented for the cell-chemotherapy of cancer. Polarized-macrophages were used both as therapeutic tool to provide immunotherapy and as delivery vessel to target deliver chemotherapeutic drugs to tumor tissues for chemotherapy simultaneously. M1/SLNP was a multifunctional delivery system with simple structure, excellent safety, and without complex synthesis process.