Thermodynamic Models for Determination of Solid–Liquid Equilibrium of the Sarafloxacin Hydrochloride in Pure and Binary Organic Solvents from (278.15 to 333.15) K

In this study, the gravimetric method was taken to measure the solubility of the sarafloxacin hydrochloride under atmospheric pressure in methanol, isopropanol, ethanol, 1-butanol, acetonitrile, n-hexane, ethyl acetate, and N,N-dimethylformamide as well as in the (ethyl acetate + acetonitrile), (methanol + n-hexane), and (ethyl acetate + n-hexane) mixtures from 278.15 to 333.15 K. The solubility of sarafloxacin hydrochloride increased with increasing temperature in all the solvents. The solid–liquid solubility equilibrium data in the pure and mixed solvents were in apparent agreement with the solubility predicted by the modified Apelblat model, Buchowski–Ksiazaczak λh model, Redlich–Kister (CNIBS/R-K) model, and Jouyban–Acree model. However, the Redlich–Kister (CNIBS/R-K) model best simulated the experimental solubility results.