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Tumor Microenvironment Cascade-Responsive Nanodrug with Self-Targeting Activation and ROS Regeneration for Synergistic Oxidation-Chemotherapy

Journal 2020 · IF 12.264 · 12(1): 1-18 · 发表于 2020 年 9 月 14 日
作者: Li Yang,Lin Jinyan,Wang Peiyuan,Luo Qiang,Zhu Fukai,Zhang Yun,Hou Zhenqing,Liu Xiaolong,Liu Jingfeng
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摘要

A pH/ROS cascade-responsive carrier-free nanodrug with self-targeting activation and ROS regeneration abilities. On-demand release of VES in response to intracellular ROS to accelerate drug release via positive-feedback loop. Highly synergistic therapeutic efficiency via orchestrated cooperation of oxidation-chemotherapy.

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