An electroanalytical method for glabridin investigation based on poly(diallyldimethylammonium chloride)-functionalized graphene-modified electrode

This paper reports on the first electrochemical investigation of glabridin . Under hydrothermal conditions, poly(diallyldimethylammonium chloride) (PDDA) was attached to a graphene (GR) surface via a noncovalent reaction. Moreover, the morphology and structure of PDDA-GR were characterized by transmission electron microscopy (TEM), Fourier transform-infrared   (FT-IR) spectroscopy and X-ray   diffraction   (XRD) analysis. Based on the nanocomposite, a (PDDA-GR/GCE) sensor was prepared, which showed a significant voltammetric response to glabridin. A simple voltammetric method for the investigation of glabridin with a wide concentration range (6.0 × 10 −8  mol L −1 –6.0 × 10 −6  mol L −1 ) and a low detection limit (2.0 × 10 −8  mol L −1 ) was proposed. The kinetic parameters were calculated, and the reaction mechanism of glabridin was obtained. Additionally, when employed for the analysis of real-life samples, the proposed method showed high accuracy and selectivity.