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Soft Mesoporous Organosilica Nanoplatforms Improve Blood Circulation, Tumor Accumulation/Penetration, and Photodynamic Efficacy

Journal 2020 · IF 12.264 · 12(1): 1-19 · 发表于 2020 年 6 月 30 日
作者: Peng Xin,Chen Kun,Liu Wanhua,Cao Xiongfeng,Wang Mengru,Tao Jun,Tian Ying,Bao Lei,Lu Guangming,Teng Zhaogang
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摘要

Soft mesoporous organosilica nanoplatforms modified with hyaluronic acid and cyanine 5.5 are constructed. Therapeutic efficacy of the soft nanoplatforms on tumor is higher both in vitro and in vivo after loading photosensitizer chlorin e6 compared to that of stiff counterparts.

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