A PTFE helical capillary microreactor for the high throughput synthesis of monodisperse silica particles

We propose a simple and inexpensive SiO 2 submicron particle synthesis method based on a PTFE helical capillary microreactor. The device is based on Dean flow mediated, ultrafast mixing of two liquid phases in a microfluidic spiral pipe. Excellent control of particle size between 100 nm and 600 nm and narrow polydispersity can be achieved by controlling the device and process parameters. Numerical simulations are performed to determine the optimal device dimensions. In the mother liquor the silica particles exhibit zeta potentials < −60 mV, rendering them very stable even at high particle volume fractions . The current device typically produces around 0.234 g/h of the silica particles.