Electrochemical Reaction Mechanism of Nitrofurazone at Poly-ACBK/GCE and Its Analytic Application

In this paper, an electrochemical sensor based on depositing acid chrome blue K on the surface of glassy carbon electrode was developed for detection of nitrofurazone. The obtained poly-ACBK film was characterised by atomic force microscope. The experimental results indicated that the Poly-ACBK/GCE showed good electrocatalytic activity to the redox reactions of nitrofurazone by differential pulse voltammetry and cyclic voltammetry in Britton-Robinson buffer solution, and the different redox peak currents were observed in different pH ranges (2.0–6.0, 7.0–12.0). Base on these, electrochemical reaction mechanism of nitrofurazone was presented in different pH ranges. Under the optimal conditions, a linear relationship between the reduction peak currents and concentrations for nitrofurazone is figured out in the range of 0.75‒192 μM, with detection limits of 0.25 µM (S/N = 3). This sensor produced satisfactory reproducibility and stability and was successfully applied to monitor of nitrofurazone in real samples (nasal drops).