In vitro dissolution study on inclusion complex of piperine with ethylenediamine-β-cyclodextrin

The co-evaporation method was used to synthesize the EN-β-CD@Piperine inclusion complex with a molar ratio of 1:1. The properties and structures of the inclusion complex were characterized by various methods to investigate the inclusion mode and interactions between host and guest. The results of molecular modeling were theoretically analyzed to determine the inclusion mechanism of inclusion complexes. Finally, the vitro dissolution release studies showed that the water solubility of piperine was significantly enhanced when EN-β-CD was combined with piperine. Therefore, the EN-β-CD@Piperine inclusion complex provides a promising development for the clinical application of piperine in the future.