A novel nonenzymatic electrochemical sensor based on double-shelled CuCo2O4 hollow microspheres for glucose and H2O2

Cu x Co 3-x O 4 (x = 0.5, 1, 1.5, 2) are successfully synthesized through hydrothermal and calcination processes. A series of electrochemical tests reveal that all of them exhibit electrocatalytic activity towards glucose and H 2 O 2 . Among them, CuCo 2 O 4 (x = 1) has a unique double-shelled hollow structure and shows higher catalytic performance. The electrochemical sensor based on CuCo 2 O 4 displays a linear range from 2.5 μM to 7.9 mM, with a sensitivity of 400.0 μA mM −1 cm −2 for the detection of glucose. As for H 2 O 2 , it shows a linear range from 10.0 μM to 8.9 mM, with a sensitivity of 94.1 μA mM −1 cm −2 . The sensor also exhibits short response time (<3 s), good selectivity, reproducibility, and stability over 18 days. Thus, this novel non-enzyme sensor has potential application in glucose and H 2 O 2 detection.