Potential Therapeutic Effects of Mg/HCOOH Metal Organic Framework on Relieving Osteoarthritis

Graphical Framework for strong bones : We explored the potential therapeutic effects of magnesium-based metal organic frameworks (MOFs) in osteoarthritis (OA). Mg/HCOOH−MOF was introduced and characterized by SEM, XRD, TGA, and FTIR. ICP−MS data proved that Mg/HCOOH−MOF is stable in various physiological media and can maintain the release of Mg 2+ ions for a long period. MTT assays showed that it is biocompatible and can promote cell proliferation, while qPCR results indicated its activity in anti-inflammation and bone protection, making Mg/HCOOH−MOF potentially suitable for treating OA. This study was designed to explore the potential therapeutic effects of Mg-based metal organic frameworks (MOFs) in osteoarthritis (OA) and to broaden the application field of MOFs. Mg/HCOOH−MOF was introduced and characterized by using SEM, XRD, TGA, and FTIR. ICP-MS results proved that Mg/HCOOH−MOF is stable in various physiological media and can maintain the release of Mg 2+ ions for a long time. In vitro experiments were carried out to evaluate its potential application in attenuating OA. Mg/HCOOH−MOF was successfully synthesized, and results of MTT assays showed that it is biocompatible and can promote cell proliferation. qPCR results suggested that it can significantly regulate the expression of OCN, Axin2, iNOS and IL-1β, which indicated its activity in anti-inflammation and bone protection. We believe that Mg/HCOOH−MOF could benefit OA therapy.