Syntheses, crystal structure and biological evaluation of three novel Cu (II) complexes with Schiff base derived from fluorinated amino acid and Salicylaldehyde

Three novel Cu (II) coordination complexes, formulated as [Cu 3 (C 14 H 8 NO 3 F) 2 (CH 3 COO) 2 ] n ( 1 ), [Cu 2 (C 14 H 9 NO 3 F) 2 (CH 3 COO)Cl] ( 2 ) and [Cu(C 14 H 8 NO 3 F)(CH 3 OH) 2 ] ( 3 ), have been synthesized by 3-Fluoroanthranilic acid, Salicylaldehyde and Cu (II) salt as sources in different reaction conditions and characterized by single crystal X-ray diffraction, X-ray powder diffraction, IR spectroscopy and elemental analysis. Single-crystal diffraction analysis revealed that the complexes exhibited different coordination modes and conformations which were linked into multidimensional networks through some weak interactions. The biological activities vary greatly on account of the different Cu (II) numbers among the three complexes. In order to discuss the bioactivities, the complexes have been screened for antimicrobial activities against E. coli and S. aureus , antitumor activities against A549 (human lung cancer cells), Hela (human cervical cancer cells) and HepG-2(human liver hepatocellular carcinoma cells). Their interactions with calf thymus DNA were investigated by UV–visible and fluorescence spectrometry, as well as viscosity measurements. Interestingly, 1 (the rare 3-core Cu (II) coordination polymer) shows great antibacterial activities and highest DNA binding affinities. Antitumor studies revealed that complex 1 also exhibited highest activity.