Four new phenylethanoid glycosides from Ternstroemia gymnanthera and their analgesic activities

Four new phenylethanoid glycosides, terngymnosides A–D ( 1 – 4 ), together with sixteen known compounds ( 5 – 20 ) were isolated from the aerial parts of Ternstroemia gymnanthera . Structures of the isolated compounds were determined by the comprehensive analyses of the physicochemical properties and spectral data (1D NMR, 2D NMR, and MS). Compounds 1 – 3 , 8 and 10 showed significant analgesic effect with the inhibition rates ranging from 56.2% to 65.3% at a dose of 50 mg/kg, that was superior to the standard drug aspirin and was equivalent to indomethacin.