Hollow copper sulfide nanocubes as multifunctional nanozymes for colorimetric detection of dopamine and electrochemical detection of glucose

Nanozymes have fascinated increasing attention in the field of artificial enzyme . Designing an ideal nanozyme usually requires a synergic advantage of reasonable nanostructures and large specific surface area for ensuring excellent mimicking-enzyme catalytic activity . Here we report a CuS nanozyme with hollow nanocube structure (h-CuS NCs), which has a large surface area of 57.84 m 2  g −1 , and thus realizes excellent mimicking-enzyme catalytic activity . Expectedly, our directed design of h-CuS NCs nanozymes has an affinity for H 2 O 2 of 0.94 mM, which is outstanding among the state-of-the-art Cu-based nanozymes. Furthermore, this nanozyme acts as a multifunctional catalyst to induce luminol chemiluminescence and oxide 3, 3′, 5, 5′-tetramethylbenzidine (TMB) in the presence of H 2 O 2 , and displays distinguished electrocatalytic activity to glucose oxidation . More intriguingly, the nanozyme can produce a promising photothermal effect under the illumination of near-infrared light. This work will provide a prototype for rational design of distinct nanostructures as multifunctional nanozymes in the area of electrochemical sensing, mimicking-enzyme catalytic biosening and cancer therapy.