Nanocomposites of Pt nanoparticles anchored on UiO66-NH2 as carriers to construct acetylcholinesterase biosensors for organophosphorus pesticide detection

Pt nanoparticle-anchored zirconium-based metal organic framework nanocomposites (Pt@UiO66-NH 2 ) with large surface areas and highly dispersed Pt nanoparticles were synthesized and applied to prepare acetylcholinesterase (AChE) biosensors for organophosphorus pesticides (OPs) detection. Because of integrative impact of excellent electron conduction channels and the increasing of adsorption sites of Pt@UiO66-NH 2 as well as the ultrahigh surface area to increase AChE immobilization, the prepared biosensors exhibited high sensitivity towards malathion (as a model for OPs), malathion was detected ranging from 1 × 10 −14  M to 1 × 10 −9  M and 4.9 × 10 −15  M was regarded as limit of detection. The biosensors also displayed accurately. Moreover, the Pt@UiO66-NH 2 /GCE was used to detect OPs in cabbage and apple samples. This study manifests the profound potential of metal nanoparticle/MOF composites for biosensors with improved electrochemical performance.