Novel antibacterial fibers of amphiphilic N-halamine polymer prepared by electrospinning

As a significant role in subcategory of halogen antibacterial field, amphiphilic N -halamine polymers show a promise as potential antimicrobials having a broad spectrum of microorganisms, long-term stability, and renewal of their antibacterial properties. By controlling the process parameters, electrospinning has been well recognized as a versatile and effective method being capable of making fibers and could be easily engineered with desired pore size and porosity to enhance the antimicrobial properties. The amphiphilic N -halamine P (ADMH-MMA-HEMA) terpolymer fibers showed efficient antimicrobial properties against both Gram-positive and Gram-negative bacteria within brief contact time. The result meant that the polymer fibers of macromolecular architecture with control of structural parameters such as hydrophobicity/hydrophilicity balance achievement improved antimicrobial activities via electrospinning technique. In vitro cytotoxicity study demonstrated that the polymer was biocompatible. As a result, the integration of amphiphilic antibacterial materials and the electrospinning technique provided us a feasible method to fabricate biocompatible antimicrobial products easily with low manufacturing cost and would be applied in many promising application areas.