Bifunctional Microbead Carriers with Magnetic Response and Plasmonic Fluorescence Enhancement

In this work, we combine the magnetic microbeads fabricated by microfluidics with nanoplasmonic-assisted fluorescence enhancement for the first time. These bifunctional microbeads not only have high fluorescence enhancement factor but also have magnetic response. The magnetic polymer microbeads were generated by capillary microfluidic device and then coated uniformly by the gold nano-islands layer. By enhancing the electric field and improving the quantum yield of the fluorescent dye, the fluorescence intensity of Dylight 800 dye has increased about 121 fold. These results demonstrate that these fluorescence enhancement magnetic microbeads have potential for developing high sensitively automatic detection systems.