Biocatalytic One-Pot Three-Component Synthesis of Indoloquinolizines with High Diastereoselectivity

A facile and green method catalyzed by α-amylase has been developed for the synthesis of highly substituted indoloquinolizines using tryptamines, β-ketoesters and α,β-unsaturated aldehydes. The reaction afforded a variety of products in moderate to good yields and with high diastereoselectivity. The densely functionalized products were obtained in a single synthetic operation under mild conditions. Graphical Abstract