Multiple Physically Cross-Linked F127−α-CD Hydrogels: Preparation, Sol–Gel Transformation, and Controlled Release of 5-Fluorouracil

Pluronic F127 is a thermosensitive polymer that has been extensively studied and utilized in biomedicine. To improve the gelation properties of F127, α-cyclodextrin was introduced by physical interactions, such as forming inclusion complexes, hydrogen bond self-assembly, and hydrophobic interactions, to prepare F127−α-CD hydrogels. This study explored the temperature-dependent sol–gel transition behavior, gelation mechanism, interior morphology, and controlled release of the anticancer drug 5-fluorouracil. Results showed that hydrogel could be obtained at 1.0%–8.0% weight content of F127. The cross-linking points in this system were PEO−α-CD microcrystalline region and micelle with poly(propylene oxide) as the core. The network inside F127−α-CD hydrogels made it stable and conducive for controlled release. Therefore, this hydrogel is a promising drug release system.