Photoreactive benzophenone as anchor of modifier to construct durable anti-platelets polymer surface

Surface modification is an effective method to improve the anti-platelets property for blood-contacting biomedical materials. However, for elastomer it is still a challenge to develop a simple and versatile method to preserve desirable property of the modified surface upon repeated deformation. Herein, we synthesized a novel modifier based on the photoreactive benzophenone (BP), which is served as anchor to fix polyethylene glycols (PEG)s onto polymer surface so as to achieve durable anti-platelets surface. Upon ultra-violet (UV) exposure for a very short time, this modifier (BP-PEG) was chemically bonded onto polyurethane (PU) so that its surface property was improved. When increasing the molecular weight or incorporating sulfonate group into BP-PEG, the anti-platelets surface of PU was obtained and this property still could be preserved upon repeated deformation. The universality of this surface modifier was verified by its successful application to the other polymer substrates and improved hydrophilicity. We anticipate this work would pave a new way to construct durable surface with unique property for biomedical devices.