Acyl atractyligenin and carboxyatractyligenin glycosides from Antennaria rosea subsp. confinis

Eight previously undescribed acyl atractyligenin and carboxyatractyligenin glycosides were isolated from whole Antennaria rosea subsp. confinis (Greene) R. J. Bayer (Compositae) [syn. Leontopodium leontopodioides (Willd.) Beauv. (Asteraceae)] plants and their structures were determined by spectroscopic and chemical methods. The compounds were trivially named leontopodiosides F–M. Seven of the compounds showed potent in vitro inhibitory activity toward pancreatic lipase with IC 50 values ranging from 3.4 to 52.5 μM, suggesting that they participate in the previously observed effect this plant has in reducing triglyceride absorption in rats.