Stimuli-Responsive Nano-polymer Composite Materials Based on the Triazine Skeleton Structure Used in Drug Delivery

Herein, we exploit the unique structure, high surface area and porous structure of covalent triazine polymers (CTP) for efficient and targeted drug delivery. We have designed and synthesized a nano-covalent triazine polymer (NCTP) by using Friedel–Crafts reactions and utilized it as a drug carrier for controlled release. The salient features of as-prepared NCTP include excellent dispersibility in physiologic solution and structural stability. Furthermore, we have achieved excellent loading of doxorubicin (DOX), an anticancer drug, onto the NCTP by utilizing the π – π interactions and hydrophobic nature. The toxicity of as-prepared NCTP was assessed by CaSki and HeLa cells, and high efficacy in vitro against both types of cells has been demonstrated.