The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives

A series of chemsensors ( 1 – 4 ) containing fluorobenzene group based on coumarin derivatives have been developed for the selective and sensitive detection of H 2 S. The advantages of the synthesized fluorescent probe (compound 1 ) were the low detection limit (4 × 10 −6 mol·L −1 ), good selectivity and high sensitivity which had been demonstrated through UV-vis, fluorescent titration experiments. Besides cytotoxicity test of compounds ( 1 and 2 ) was studied and the results indicated that compounds ( 1 and 2 ) showed almost no cytotoxicityat at a concentration of 150 μg·mL −1 . The interacted mechanism was the thiolysis reaction of dinitrophenyl ether which had been confirmed by fluorescence and HRMS titration experiment. In addition, probe 1 can also detect HS − selectively by naked eye in pure DMSO solvent.