Controllable synthesis of highly monodispersed nanoscale Fe-soc-MOF and the construction of Fe-soc-MOF@polypyrrole core-shell nanohybrids for cancer therapy

Nanoscale metal-organic frameworks (NMOFs) are promising porous nanomaterials for various applications, such as catalysis, biomedical imaging, drug delivery and cancer therapy etc . Especially when it comes to medical applications, downsizing of MOFs into nanoscale is the crucial requirement. Herein, liquid-solid-solution (LSS) method was used to prepare nano Fe- soc -MOF for the first time, and then we integrated the as-synthesized nanoscale Fe- soc -MOF with polypyrrole (PPy) to construct a multifunctional theranostic platform. The novel Fe- soc -MOF@PPy core-shell nanohybrids can be triggered by the 808 nm laser irradiation to produce photothermal effect for cancer therapy. The photothermal therapy (PTT) was performed both in vitro and in vivo . This work demonstrates the great potential of the MOF nanocomposites for cancer diagnosis and treatment.