Preparation of a molecularly imprinted polymer based chemiluminescence sensor for the determination of amantadine and rimantadine in meat

The residues of amantadine and rimantadine in foods of animal origin are dangerous to consumers. This study used adamantane as the dummy template for the first time to synthesize a molecularly imprinted polymer capable of simultaneously recognizing amantadine and rimantadine. This polymer was used as the recognition reagent to prepare a chemiluminescence sensor on the conventional 96-well microtiter plate for the determination of the two drugs in chicken and pork samples. The results showed that one test could be finished within 20 min, and the sensor could be reused 6 times. Due to the 4-(imidazol-1-yl)phenol enhanced luminol–H2O2 signal system, the limit of detection for the two analytes was 1.0 pg mL−1. The recoveries of the two analytes from the standard fortified blank meat samples were in the range of 67.2–93.5%. Therefore, the sensor could be used as a simple, rapid, sensitive, specific and recyclable tool for the routine monitoring of the residues of amantadine and rimantadine in meat.