Porous GdAlO3: Cr3+, Sm3+ drug carrier for real-time long afterglow and magnetic resonance dual-mode imaging

Here, a kind of porous nanoparticles GdAlO 3 :Cr 3+ , Sm 3+ (GAO:Cr,Sm) which own magnetic resonance and long persistent luminescent properties have been synthesized. The spherical morphology and narrow size distribution would allow the GAO:Cr,Sm nanoparticles to be utilised as a drug carrier and the drug release results indicate that the GAO:Cr,Sm drug carriers have an excellent drug sustained properties. Applying the Cr 3+ and Sm 3+ coped with gadolinium aluminate as the NIR persistent luminescence center and the energy transfer resonance from Gd 3+ to Cr 3+ , these nanoparticles exhibit excellent NIR persistent luminescence at 732 nm under the UV irradiation of 254 nm and it can persist for about half an hour. In addition, they possess a longitudinal relaxivity (r 1 ) value of 4.75 mM −1 s −1 , which means that these nanoparticles could be applied for MR imaging as contrast agents. Carboxymethyl Chitosan was modified on the surface of GAO:Cr,Sm nanoparticles to make them owning excellent biocompatibility and low toxicity and these nanoparticles were successful to realize in vivo imaging. Hence, the well-defined nanoprobes of GAO:Cr,Sm exhibit great potential in biomedicine as trackable drug carriers and in vivo imaging agent due to the dual-model imaging property.