Vc-Functionalized Fe3O4 Nanocomposites as Peroxidase-like Mimetics for H2O2 and Glucose Sensing

A simple and efficient colorimetric biosensing for hydrogen peroxide and glucose with peroxidase-like vitamin C(V c ) functionalized Fe 3 O 4 magnetic nanoparticles(V c Fe 3 O 4 MNPs) as a catalyst is reported. Compared with Fe 3 O 4 MNPs and other catalysts, V c Fe 3 O 4 MNPs exhibited superior catalytic properties. Kinetic studies indicated that vitamin C incorporated on Fe 3 O 4 MNPs improved the affinity toward H 2 O 2 . As low as 0.29 μmol/L H 2 O 2 can be detected with a wide linear range of 0.5―100 μmol/L H 2 O 2 ; moreover, as low as 0.288 μmol/L glucose can be detected with a linear range of 0.5―25 μmol/L glucose. The detection method was highly sensitive in sensing H 2 O 2 and glucose. The robustness of V c Fe 3 O 4 MNPs rendered them suitable for wide ranging applications.